7-amino-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (diphenylmethyl) ester hydrochloride
7-Amino-8-oxo-3-(cis-prop-1-enyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester hydrochloride
CAS: 106447-41-0
Molecular Formula: C23H22N2O3S
7-amino-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (diphenylmethyl) ester hydrochloride - Names and Identifiers
| Name | 7-Amino-8-oxo-3-(cis-prop-1-enyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester hydrochloride |
| Synonyms | (6R,7R)-Benzhydryl 7-amino-8-oxo-3-((Z)-prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7-amino-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (diphenylmethyl) ester hydrochloride 7-Amino-8-oxo-3-(cis-prop-1-enyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester hydrochloride 7-AMINO-8-OXO-3-(CIS-PROP-1-ENYL)-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID DIPHENYLMETHYL ESTER HYDROCHLORIDE |
| CAS | 106447-41-0 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C23H22N2O3S.ClH/c1-2-9-17-14-29-22-18(24)21(26)25(22)19(17)23(27)28-20(15-10-5-3-6-11-15)16-12-7-4-8-13-16;/h2-13,18,20,22H,14,24H2,1H3;1H |
7-amino-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (diphenylmethyl) ester hydrochloride - Physico-chemical Properties
| Molecular Formula | C23H22N2O3S |
| Molar Mass | 406.5 |
7-amino-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (diphenylmethyl) ester hydrochloride - Introduction
7-Amino-8-oxo-3-(cis-1-enyl)-5-thia-1-azabicyclo [4,2,0] oct-2-ene-2-carboxylic acid diphenyl methyl ester hydrochloride is the name of a compound commonly referred to simply as HOBt · HCl. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White solid
-Molecular formula: C18H21N3O5S · HCl
-Molecular weight: 415.9g/mol
-Melting point: 140-143°C
-Soluble: Soluble in water, ethanol and dimethyl sulfoxide
Use:
HOBt · HCl is a commonly used reagent in organic chemistry, which is mainly used as a catalyst or an introducing agent of protecting group in peptide synthesis reaction. It can improve the selectivity of the peptide chain, reduce the occurrence of side reactions and improve the yield. In peptide synthesis, HOBt. HCl is often used with activators such as DIC, HBTU, and the like.
Preparation Method:
The preparation method of HOBt · HCl is relatively simple, and HOBt · HCl can be obtained by first reacting HOBt with hydrochloric acid. Specific steps are as follows:
1. Dissolve HOBt in an organic solvent, such as dimethyl sulfoxide (DMSO) or methanol.
2. Add excess hydrochloric acid to the solution.
3. Stir the reaction at room temperature for a period of time.
4. Filtration yields a solid product, which may be further washed and dried.
Safety Information:
- HOBt · HCl is a relatively safe reagent under general conditions of use.
-Avoid direct contact with eyes, skin and mucous membranes during operation. In case of contact, rinse immediately with plenty of water and seek medical attention.
-Use in a well-ventilated environment to avoid inhalation of dust or gas.
-storage should be sealed, away from high temperature, fire and oxidant.
-The use of HOBt · HCl in food, beverages and animal feed is prohibited.
Please note that the use and handling of chemicals must follow laboratory safety practices and refer to specific chemical safety data sheets (SDS) and relevant test manuals. If you need to know more about or use the compound, please consult a professional.
Nature:
-Appearance: White solid
-Molecular formula: C18H21N3O5S · HCl
-Molecular weight: 415.9g/mol
-Melting point: 140-143°C
-Soluble: Soluble in water, ethanol and dimethyl sulfoxide
Use:
HOBt · HCl is a commonly used reagent in organic chemistry, which is mainly used as a catalyst or an introducing agent of protecting group in peptide synthesis reaction. It can improve the selectivity of the peptide chain, reduce the occurrence of side reactions and improve the yield. In peptide synthesis, HOBt. HCl is often used with activators such as DIC, HBTU, and the like.
Preparation Method:
The preparation method of HOBt · HCl is relatively simple, and HOBt · HCl can be obtained by first reacting HOBt with hydrochloric acid. Specific steps are as follows:
1. Dissolve HOBt in an organic solvent, such as dimethyl sulfoxide (DMSO) or methanol.
2. Add excess hydrochloric acid to the solution.
3. Stir the reaction at room temperature for a period of time.
4. Filtration yields a solid product, which may be further washed and dried.
Safety Information:
- HOBt · HCl is a relatively safe reagent under general conditions of use.
-Avoid direct contact with eyes, skin and mucous membranes during operation. In case of contact, rinse immediately with plenty of water and seek medical attention.
-Use in a well-ventilated environment to avoid inhalation of dust or gas.
-storage should be sealed, away from high temperature, fire and oxidant.
-The use of HOBt · HCl in food, beverages and animal feed is prohibited.
Please note that the use and handling of chemicals must follow laboratory safety practices and refer to specific chemical safety data sheets (SDS) and relevant test manuals. If you need to know more about or use the compound, please consult a professional.
Last Update：2024-04-09 19:05:44
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